HealthResearch Observes Effects of Mental Health Issues on Telomeres and Aging

Research Observes Effects of Mental Health Issues on Telomeres and Aging

It has become widely thought among healthcare professionals and the public alike that mental health affects physical well-being. New research suggests that depression and anxiety may speed up the aging process, leading to the development of chronic disease. Here, I discuss my research on the link between depression, anxiety, and short telomere length – a condition wherein the protective caps at the ends of cells are shortened to the point wherein those cells no longer divide.

Linking Telomere Length to Aging and Disease

For the past ten years, I have been interested in identifying the various mechanisms by which mental health problems, such as depression and anxiety, influence the development of chronic physical health problems, such as cardiovascular disease. My most recent work in this area examined associations between depression, anxiety, and telomere length, a potential biological mechanism linking mental health problems to morbidity and mortality.

Telomeres are the protective caps at the ends of chromosomes that shorten each time a cell divides. Eventually, critically shortened telomeres trigger cellular senescence, when cells essentially get old and stop dividing. Therefore, telomere length is thought to be a biological marker of aging. In support of this theory, a growing number of studies have shown that shorter telomere length is associated with diseases of aging, including cardiovascular disease, type 2 diabetes, dementia, and cancer, independent of chronological age. In addition, some studies have found that shorter telomere length predicts increased risk of death.

Women with Anxiety Found to Have Shorter Telomere Length

To examine the hypothesis that anxiety and depression are associated with shorter telomeres, my coauthors and I used data collected between 1999 and 2002 from the National Health and Nutrition Examination Survey (NHANES).1 In all, our study included 1,164 white, African-American, and Mexican-American participants between the ages of 20 and 39, some of whom had major depression, Generalized Anxiety Disorder, or panic disorder in the past year. Among female study participants, those with anxiety or panic disorder had shorter telomeres than similar women who reported no symptoms of anxiety. No association was found between anxiety disorders and telomere length among men.

More Severe Depression Could Be Linked to Shorter Telomeres in Young Adults

In the full sample, no association was found between major depression and telomere length. Among current antidepressant users, however, those with major depression had shorter telomeres than those who reported no symptoms of depression. A small amount (4.5%) of respondents reported current antidepressant use.

Antidepressant use was more frequent among participants with depression or anxiety, but was also reported by those with no depressive or anxious symptoms. We found no association between current antidepressant use and telomere length in the full sample, only for those who had depression in the past year despite current use of antidepressant medications.

Further Research on Telomere Length and Mental Health is Needed

Due to the fact that the study is observational, the conclusion that mental health problems cause short telomeres remains tentative. Longer term studies in the same individuals could help determine whether changes in mental health are associated with changes in telomere length over time, providing stronger evidence for a causal association.

I hope that our study will encourage research on the biological mechanisms linking mental health disorders to physical health problems, and inspire health care providers, policymakers, and the public to recognize the importance of mental health problems for overall health and well-being.

Research on the link between mental and physical health tells us that our minds and bodies are connected. If you or someone you know are experiencing symptoms of depression or anxiety, and you are worried about the physical health consequences, talk to your doctor about treatment options.


Needham BL, Mezuk B, Bareis N, Lin J, Blackburn EH, Epel ES. Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey. Mol Psychiatry. 2015 Apr;20(4):520-8

Assistant Professor of Epidemiology at University of Michigan

Belinda Needham, Ph.D., is currently Assistant Professor of Epidemiology at the University of Michigan in Ann Arbor, MI. She received her bachelor’s degree in sociology from Texas A&M University and both her master’s and doctoral degrees in sociology from the University of Texas at Austin. Her dissertation was honored with an award for the Best Dissertation in Mental Health from the American Sociological Association.

Dr. Needham completed postdoctoral training in population health at the University of California, San Francisco and Berkeley as part of the Robert Wood Johnson Health and Society Scholars Program. She was part of the research team that received a grant from the National Institutes of Health to add data on telomere length to the National Health and Nutrition Examination Survey. Her current work focuses on health disparities, medical and psychiatric comorbidity, and aging and the life course.


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