Nicotinamide mononucleotide (NMN) along with resveratrol are two anti-aging supplements gaining traction in the longevity domain. In tandem, they might reduce cellular aging and offer additional beneficial effects to the human physiology. This pairing is thought to enhance strength, boost physical stamina, and amplify blood circulation.
What is NMN?
NMN is short for Nicotinamide Mononucleotide, which is an important substance that helps produce nicotinamide adenine dinucleotide (NAD+). NAD+ is a crucial enzyme involved in various cellular functions like metabolism, cell development and overall cell health. NMN plays a significant role in boosting energy levels and supporting the renewal of cells.
Research has indicated that NMN can amplify NAD+ synthesis and enhance disease detection in lab mice. In an early study on NMN, mice given an NMN supplement witnessed a spike in tissue NMN and NAD+ levels within 15 minutes in organs like the liver, pancreas, and white fat tissue. To ensure prolonged NMN consumption, another team gave mice reduced doses, anticipating this could eventually display promising anti-aging results in humans when incorporated into drinking water.
Long-term impacts of NMN supplementation:
To evaluate the long-term outcomes of NMN usage, a year-long study was initiated. Preliminary results suggested that consistent NMN consumption notably curbed age-related weight increase. Remarkably, NMN-treated mice consumed more food but gained less weight than the control group. These mice also exhibited boosted energy metabolism, heightened physical activity, and improved oxygen intake.Furthermore, the research indicated that NMN has the potential to combat aging at a molecular level by reversing changes in gene expression associated with aging. Subsequently, more than 27 additional studies were conducted to evaluate the effects of NMN on mice, uncovering its ability to:
- Enhance glucose tolerance and insulin production.
- Minimize damage post-ischemia.
- Diminish inflammation and neuronal cell death.
- Revitalize physical activity.
- Augment learning, memory, and cognitive capabilities.
- Bolster cardiac functions.
- Lessen DNA damage.